BOK promotes chemical-induced hepatocarcinogenesis in mice
نویسندگان
چکیده
منابع مشابه
Histone modification enzymes induced during chemical hepatocarcinogenesis.
Aberrant methylation patterns of genomic DNA are well-studied epigenetic mutations in cancer. Hypermethylation of CpG islands in tumor-suppressor genes promotes oncogenesis and hypomethylation of global genomic DNA affects genomic stability. Cancer is recognized as a genetic and epigenetic disease. However, it is not clear how epigenetic regulatory factors, including histone modification enzyme...
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To elucidate the mechanism of hepatocarcinogenesis of pentachlorophenol (PCP) in mice, critical effects related to carcinogenicity were studied in the livers of B6C3F1 male mice administered PCP at concentrations of 600 and 1200 p.p.m. in the diet for 8 weeks. Oxidative stress was assessed by measurements of 8-oxodeoxyguanosine (8-oxodG) in the liver nuclear DNA and hepatocyte cell proliferatio...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2017
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-017-0008-0